SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation

The mTORC1 pathway coordinates nutrient and growth factor signals to maintain organismal homeostasis. Whether nutrient signaling to mTORC1 regulates stem cell function remains unknown. Here, we show that SZT2 — a protein required for mTORC1 downregulation upon nutrient deprivation — is critical for...

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Detalles Bibliográficos
Autores principales: Yin, Na, Jin, Gang, Ma, Yuying, Zhao, Hanfei, Zhang, Guangyue, Li, Ming O., Peng, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566891/
https://www.ncbi.nlm.nih.gov/pubmed/36250465
http://dx.doi.org/10.1172/JCI146272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9566891/
https://www.ncbi.nlm.nih.gov/pubmed/36250465
http://dx.doi.org/10.1172/JCI146272

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