ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma

Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is typically initiated by inactivation of the von Hippel Lindau (VHL) gene, which results in the constitutive activation of the hypoxia inducible factors, HIF-1α and HIF-2α. Using a high throughput screen, we identify no...

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Detalles Bibliográficos
Autores principales: Green, Yangsook Song, Ferreira dos Santos, Maria C., Fuja, Daniel G., Reichert, Ethan C., Campos, Alexandre R., Cowman, Sophie J., Acuña Pilarte, Karen, Kohan, Jessica, Tripp, Sheryl R., Leibold, Elizabeth A., Sirohi, Deepika, Agarwal, Neeraj, Liu, Xiaohui, Koh, Mei Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568429/
https://www.ncbi.nlm.nih.gov/pubmed/36097192
http://dx.doi.org/10.1038/s41388-022-02460-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568429/
https://www.ncbi.nlm.nih.gov/pubmed/36097192
http://dx.doi.org/10.1038/s41388-022-02460-1

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