HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated with HERC2 Angelman-like syndrome. In pathogenic HERC2 variants, complete absence...

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Detalles Bibliográficos
Autores principales: Sala-Gaston, Joan, Pedrazza, Leonardo, Ramirez, Juanma, Martinez-Martinez, Arturo, Rawlins, Lettie E., Baple, Emma L., Crosby, Andrew H., Mayor, Ugo, Ventura, Francesc, Rosa, Jose Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568463/
https://www.ncbi.nlm.nih.gov/pubmed/36241744
http://dx.doi.org/10.1007/s00018-022-04586-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568463/
https://www.ncbi.nlm.nih.gov/pubmed/36241744
http://dx.doi.org/10.1007/s00018-022-04586-7

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