UHPLC-MS/MS method for the simultaneous determination of nicotine and tobacco-specific nitrosamines NNN and NNK for use in preclinical studies

A new method was developed and validated for the simultaneous determination of nicotine and tobacco-specific nitrosamines (TSNAs) 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN) in two different tests matrices: porcine buccal epithelium tissue and phosphate buffer...

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Detalles Bibliográficos
Autores principales: Meikopoulos, Thomas, Begou, Olga, Panagoulis, Theodoros, Kontogiannidou, Eleni, Fatouros, Dimitrios G., Miller, John H., Theodoridis, Georgios, Gika, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568479/
https://www.ncbi.nlm.nih.gov/pubmed/36163593
http://dx.doi.org/10.1007/s00216-022-04319-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568479/
https://www.ncbi.nlm.nih.gov/pubmed/36163593
http://dx.doi.org/10.1007/s00216-022-04319-6

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