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Design and function of targeted endocannabinoid nanoparticles

Nanoparticles and nano-delivery systems are constantly being refined and developed for biomedical applications such as imaging, gene therapy, and targeted delivery of drugs. Nanoparticles deliver beneficial effects by both release of their cargo and by liberation of their constitutive structural com...

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Autores principales: Barrie, N., Manolios, N., Stuart, J., Chew, T., Arnold, J., Sadsad, R., De Campo, L., Knott, R. B., White, J., Booth, D., Ali, M., Moghaddam, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568518/
https://www.ncbi.nlm.nih.gov/pubmed/36241847
http://dx.doi.org/10.1038/s41598-022-21715-1
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author Barrie, N.
Manolios, N.
Stuart, J.
Chew, T.
Arnold, J.
Sadsad, R.
De Campo, L.
Knott, R. B.
White, J.
Booth, D.
Ali, M.
Moghaddam, M. J.
author_facet Barrie, N.
Manolios, N.
Stuart, J.
Chew, T.
Arnold, J.
Sadsad, R.
De Campo, L.
Knott, R. B.
White, J.
Booth, D.
Ali, M.
Moghaddam, M. J.
author_sort Barrie, N.
collection PubMed
description Nanoparticles and nano-delivery systems are constantly being refined and developed for biomedical applications such as imaging, gene therapy, and targeted delivery of drugs. Nanoparticles deliver beneficial effects by both release of their cargo and by liberation of their constitutive structural components. The N-acylethanolamines linoleoyl ethanolamide (LEA) and oleoyl ethanolamide (OEA) both exhibit endocannabinoid-like activity. Here, we report on their ability to form nanoparticles that when conjugated with tissue-specific molecules, are capable of localizing to specific areas of the body and reducing inflammation. The facilitation of pharmacological effects by endocannabinoids at targeted sites provides a novel biocompatible drug delivery system and a therapeutic approach to the treatment, patient management and quality of life, in conditions such as arthritis, epilepsy, and cancer.
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spelling pubmed-95685182022-10-16 Design and function of targeted endocannabinoid nanoparticles Barrie, N. Manolios, N. Stuart, J. Chew, T. Arnold, J. Sadsad, R. De Campo, L. Knott, R. B. White, J. Booth, D. Ali, M. Moghaddam, M. J. Sci Rep Article Nanoparticles and nano-delivery systems are constantly being refined and developed for biomedical applications such as imaging, gene therapy, and targeted delivery of drugs. Nanoparticles deliver beneficial effects by both release of their cargo and by liberation of their constitutive structural components. The N-acylethanolamines linoleoyl ethanolamide (LEA) and oleoyl ethanolamide (OEA) both exhibit endocannabinoid-like activity. Here, we report on their ability to form nanoparticles that when conjugated with tissue-specific molecules, are capable of localizing to specific areas of the body and reducing inflammation. The facilitation of pharmacological effects by endocannabinoids at targeted sites provides a novel biocompatible drug delivery system and a therapeutic approach to the treatment, patient management and quality of life, in conditions such as arthritis, epilepsy, and cancer. Nature Publishing Group UK 2022-10-14 /pmc/articles/PMC9568518/ /pubmed/36241847 http://dx.doi.org/10.1038/s41598-022-21715-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Barrie, N.
Manolios, N.
Stuart, J.
Chew, T.
Arnold, J.
Sadsad, R.
De Campo, L.
Knott, R. B.
White, J.
Booth, D.
Ali, M.
Moghaddam, M. J.
Design and function of targeted endocannabinoid nanoparticles
title Design and function of targeted endocannabinoid nanoparticles
title_full Design and function of targeted endocannabinoid nanoparticles
title_fullStr Design and function of targeted endocannabinoid nanoparticles
title_full_unstemmed Design and function of targeted endocannabinoid nanoparticles
title_short Design and function of targeted endocannabinoid nanoparticles
title_sort design and function of targeted endocannabinoid nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568518/
https://www.ncbi.nlm.nih.gov/pubmed/36241847
http://dx.doi.org/10.1038/s41598-022-21715-1
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