Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

Disturbed lipid metabolism precedes alcoholic liver injury. Whether and how AhR alters degradation of lipids, particularly phospho-/sphingo-lipids during alcohol exposure, was not explored. Here, we show that alcohol consumption in mice results in induction and activation of aryl hydrocarbon recepto...

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Detalles Bibliográficos
Autores principales: Kim, Yun Seok, Ko, Bongsub, Kim, Da Jung, Tak, Jihoon, Han, Chang Yeob, Cho, Joo-Youn, Kim, Won, Kim, Sang Geon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568535/
https://www.ncbi.nlm.nih.gov/pubmed/36241614
http://dx.doi.org/10.1038/s41467-022-33749-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568535/
https://www.ncbi.nlm.nih.gov/pubmed/36241614
http://dx.doi.org/10.1038/s41467-022-33749-0

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