Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes

Genome duplication is safeguarded by constantly adjusting the activity of the replicative CMG (CDC45-MCM2-7-GINS) helicase. However, minichromosome maintenance proteins (MCMs)—the structural core of the CMG helicase—have never been visualized at sites of DNA synthesis inside a cell (the so-called MC...

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Detalles Bibliográficos
Autores principales: Polasek-Sedlackova, Hana, Miller, Thomas C. R., Krejci, Jana, Rask, Maj-Britt, Lukas, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568601/
https://www.ncbi.nlm.nih.gov/pubmed/36241664
http://dx.doi.org/10.1038/s41467-022-33887-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568601/
https://www.ncbi.nlm.nih.gov/pubmed/36241664
http://dx.doi.org/10.1038/s41467-022-33887-5

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