Cargando…

Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes

Genome duplication is safeguarded by constantly adjusting the activity of the replicative CMG (CDC45-MCM2-7-GINS) helicase. However, minichromosome maintenance proteins (MCMs)—the structural core of the CMG helicase—have never been visualized at sites of DNA synthesis inside a cell (the so-called MC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Polasek-Sedlackova, Hana, Miller, Thomas C. R., Krejci, Jana, Rask, Maj-Britt, Lukas, Jiri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568601/ https://www.ncbi.nlm.nih.gov/pubmed/36241664 http://dx.doi.org/10.1038/s41467-022-33887-5

Ejemplares similares

The eukaryotic CMG helicase pumpjack and integration into the replisome
por: Sun, Jingchuan, et al.
Publicado: (2016)

Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
por: Xiang, Shengyan, et al.
Publicado: (2023)

Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase
por: Maculins, Timurs, et al.
Publicado: (2015)

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
por: Costa, Alessandro, et al.
Publicado: (2014)

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome
por: Eickhoff, Patrik, et al.
Publicado: (2019)

Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome
por: Oki, Keisuke, et al.
Publicado: (2021)

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks
por: Langston, Lance D, et al.
Publicado: (2017)

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
por: Simon, Aline C., et al.
Publicado: (2014)

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
por: Deegan, Tom D, et al.
Publicado: (2020)

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
por: Lõoke, Marko, et al.
Publicado: (2017)

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase
por: Villa, Fabrizio, et al.
Publicado: (2016)

MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity
por: Das, Mitali, et al.
Publicado: (2014)

Structure of the eukaryotic replicative CMG helicase and pumpjack motion
por: Yuan, Zuanning, et al.
Publicado: (2016)

Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer
por: Reed, Damon R., et al.
Publicado: (2020)

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome
por: Goswami, Panchali, et al.
Publicado: (2018)

Structure of human Cdc45 and implications for CMG helicase function
por: Simon, Aline C., et al.
Publicado: (2016)

DNA unwinding mechanism of a eukaryotic replicative CMG helicase
por: Yuan, Zuanning, et al.
Publicado: (2020)

Mechanism of replication origin melting nucleated by CMG helicase assembly
por: Lewis, Jacob S., et al.
Publicado: (2022)

DONSON is required for CMG helicase assembly in the mammalian cell cycle
por: Evrin, Cecile, et al.
Publicado: (2023)

The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy
por: Seo, Yeon-Soo, et al.
Publicado: (2018)

Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases
por: Nepon-Sixt, Brook S., et al.
Publicado: (2019)

DNA polymerase ε-dependent modulation of the pausing property of the CMG helicase at the barrier
por: Hizume, Kohji, et al.
Publicado: (2018)

Synergism between CMG helicase and leading strand DNA polymerase at replication fork
por: Xu, Zhichun, et al.
Publicado: (2023)

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication
por: Atkinson, John, et al.
Publicado: (2011)

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
por: Kliszczak, Maciej, et al.
Publicado: (2015)

Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
por: Kose, Hazal B., et al.
Publicado: (2020)

Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks
por: Devbhandari, Sujan, et al.
Publicado: (2020)

Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication
por: Spies, Julian, et al.
Publicado: (2021)

Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function
por: Miller, Justin M., et al.
Publicado: (2015)

DNA binding and helicase actions of mouse MCM4/6/7 helicase
por: You, Zhiying, et al.
Publicado: (2005)

RAD51 and MRE11 dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks
por: Hashimoto, Yoshitami, et al.
Publicado: (2011)

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
por: Langston, Lance, et al.
Publicado: (2017)

CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
por: Ratnayeke, Nalin, et al.
Publicado: (2023)

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans
por: Xia, Yisui, et al.
Publicado: (2023)

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast
por: Mukherjee, Progya P., et al.
Publicado: (2019)

Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes
por: Le, Thanh Thi, et al.
Publicado: (2021)

Structural basis of the Methanothermobacter thermautotrophicus MCM helicase activity
por: Costa, Alessandro, et al.
Publicado: (2006)

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase
por: Simon, Nicholas, et al.
Publicado: (2013)

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication
por: Maric, Marija, et al.
Publicado: (2017)

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase—Pol ε Interaction
por: Denkiewicz-Kruk, Milena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_oulk5tg89hdkrk2tou2bb6bbuv