The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Binding to the neonatal Fc receptor (FcRn) extends serum half-life of IgG, and antagonizing this interaction is a promising therapeutic approach in IgG-mediated autoimmune diseases. Fc-MST-HN, designed for enhanced FcRn binding capacity, has not been evaluated in the context of a full-length antibod...

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Detalles Bibliográficos
Autores principales: Brinkhaus, Maximilian, Pannecoucke, Erwin, van der Kooi, Elvera J., Bentlage, Arthur E. H., Derksen, Ninotska I. L., Andries, Julie, Balbino, Bianca, Sips, Magdalena, Ulrichts, Peter, Verheesen, Peter, de Haard, Hans, Rispens, Theo, Savvides, Savvas N., Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568614/
https://www.ncbi.nlm.nih.gov/pubmed/36241613
http://dx.doi.org/10.1038/s41467-022-33764-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568614/
https://www.ncbi.nlm.nih.gov/pubmed/36241613
http://dx.doi.org/10.1038/s41467-022-33764-1

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