A randomized, double-blinded, placebo-controlled, crossover study of the HCN channel blocker ivabradine in a capsaicin-induced pain model in healthy volunteers

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been focused on as a potential therapeutic target for inflammatory and neuropathic pain in rodent models. However, roles of HCN channels in human pain states have been scarcely investigated. We evaluated analgesic effects of 2-d...

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Detalles Bibliográficos
Autores principales: Tanaka, Satoshi, Ishida, Takashi, Ishida, Kumiko, Fuseya, Satoshi, Ito, Mariko, Sakamoto, Akiyuki, Kawamata, Mikito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568658/
https://www.ncbi.nlm.nih.gov/pubmed/36241872
http://dx.doi.org/10.1038/s41598-022-22309-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568658/
https://www.ncbi.nlm.nih.gov/pubmed/36241872
http://dx.doi.org/10.1038/s41598-022-22309-7

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