Cargando…

A randomized, double-blinded, placebo-controlled, crossover study of the HCN channel blocker ivabradine in a capsaicin-induced pain model in healthy volunteers

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been focused on as a potential therapeutic target for inflammatory and neuropathic pain in rodent models. However, roles of HCN channels in human pain states have been scarcely investigated. We evaluated analgesic effects of 2-d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Satoshi, Ishida, Takashi, Ishida, Kumiko, Fuseya, Satoshi, Ito, Mariko, Sakamoto, Akiyuki, Kawamata, Mikito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568658/ https://www.ncbi.nlm.nih.gov/pubmed/36241872 http://dx.doi.org/10.1038/s41598-022-22309-7

Ejemplares similares

Airway obstruction due to a laryngeal polyp following insertion of a laryngeal mask airway
por: Fuseya, Satoshi, et al.
Publicado: (2018)

Phospholipase Cβ3 Expressed in Mouse DRGs is Involved in Inflammatory and Postoperative Pain
por: Ide, Susumu, et al.
Publicado: (2020)

Subfascial infiltration of 0.5% ropivacaine, but not 0.25% ropivacaine, exacerbates damage and inflammation in surgically incised abdominal muscles of rats
por: Shen, Dandan, et al.
Publicado: (2022)

Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure
por: Ishida, Takashi, et al.
Publicado: (2018)

Knockdown of TRPV2 channels in sensory neurons increases limb use and weight bearing but does not affect spontaneous flinching behavior in a mouse model of bone cancer
por: Yamamoto, Katsumi, et al.
Publicado: (2018)

Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels
por: Bucchi, Annalisa, et al.
Publicado: (2013)

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
por: Melgari, Dario, et al.
Publicado: (2015)

Spinal nociceptive transmission by mechanical stimulation of bone marrow
por: Ishida, Takashi, et al.
Publicado: (2016)

Severe mitral regurgitation due to geometric changes in the mitral valve after surgical aortic valve replacement
por: Wakabayashi, Ryo, et al.
Publicado: (2019)

Comparison of ivabradine plus β-blockers versus β-blocker therapy only
por: Aalbers, J
Publicado: (2010)

The Usefulness of Prioritization of Ivabradine Before Beta-Blockers in a Heart Failure Patient Suffering From Intra-hemodialysis Hypotension
por: Yamaguchi, Satoshi, et al.
Publicado: (2023)

Changes in synaptic transmission of substantia gelatinosa neurons after spinal cord hemisection revealed by analysis using in vivo patch-clamp recording
por: Kozuka, Yuji, et al.
Publicado: (2016)

Difficult Management of a Double-Lumen Endotracheal Tube and Difficult Ventilation during Robotic Thymectomy with Carbon Dioxide Insufflation
por: Sugiyama, Yuki, et al.
Publicado: (2017)

Effect of an aerosol box on tracheal intubation difficulty
por: Wakabayashi, Ryo, et al.
Publicado: (2020)

Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties
por: Nakashima, Kosuke, et al.
Publicado: (2021)

Efficacy of Ivabradine in Combination with Beta-Blockers Versus Uptitration of Beta-Blockers in Patients with Stable Angina (CONTROL-2 Study)
por: Glezer, Maria, et al.
Publicado: (2018)

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Miyake, Saki, et al.
Publicado: (2019)

Implication of Ivabradine in Up-titrating Beta-blocker in a Patient with Advanced Heart Failure
por: Hori, Masakazu, et al.
Publicado: (2020)

A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers
por: Albaugh, Vance L., et al.
Publicado: (2011)

The HCN Channel Blocker ZD7288 Induces Emesis in the Least Shrew (Cryptotis parva)
por: Zhong, W., et al.
Publicado: (2021)

McGRATH MAC video laryngoscope for insertion of a transoesophageal echocardiography probe: A randomised controlled trial
por: Ishida, Takashi, et al.
Publicado: (2016)

Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers
por: Cavallone, Laura F, et al.
Publicado: (2013)

Ivabradine in Combination with Beta-Blockers in Patients with Chronic Stable Angina After Percutaneous Coronary Intervention
por: Werdan, Karl, et al.
Publicado: (2015)

Salts of HCN‐Cyanide Aggregates: [CN(HCN)(2)](−) and [CN(HCN)(3)](−)
por: Bläsing, Kevin, et al.
Publicado: (2020)

The effect of BI 409306 on heart rate in healthy volunteers: a randomised, double-blind, placebo-controlled, crossover study
por: Müller, Fabian, et al.
Publicado: (2022)

Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers
por: Høiseth, Lars Øivind, et al.
Publicado: (2023)

Ivabradine Versus Beta-Blockers in Patients with Conduction Abnormalities or Left Ventricular Dysfunction Undergoing Cardiac Surgery
por: Iliuta, Luminita, et al.
Publicado: (2013)

Ivabradine in sepsis
por: Nair, Abhijit S, et al.
Publicado: (2013)

Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial
por: Tardif, Jean-Claude, et al.
Publicado: (2009)

Systemic Ropivacaine Diminishes Pain Sensitization Processes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Study in Healthy Volunteers
por: Haller, Yéri, et al.
Publicado: (2014)

Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers
por: Koteshwar, Pravina, et al.
Publicado: (2013)

Ivabradine Versus Beta-Blockers in Mitral Stenosis in Sinus Rhythm: An Updated Meta-Analysis of Randomized Controlled Trials
por: Ramos, John Daniel A., et al.
Publicado: (2018)

Capsaicin Analogue Supplementation Does Not Improve 10 km Running Time-Trial Performance in Male Amateur Athletes: A Randomized, Crossover, Double-Blind and Placebo-Controlled Study
por: von Ah Morano, Ana Elisa, et al.
Publicado: (2020)

Salacia Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers
por: Jeykodi, Shankaranarayanan, et al.
Publicado: (2016)

Ivabradine and endothelium: an update
por: Dallapellegrina, Lucia, et al.
Publicado: (2020)

The effects of phenylalanine on exercise-induced fat oxidation: a preliminary, double-blind, placebo-controlled, crossover trial
por: Ueda, Keisuke, et al.
Publicado: (2017)

Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes
por: Saito, Yukihiro, et al.
Publicado: (2022)

Effectiveness and Tolerability of Ivabradine with or Without Concomitant Beta-Blocker Therapy in Patients with Chronic Stable Angina in Routine Clinical Practice
por: Perings, Stefan, et al.
Publicado: (2016)

Adding ivabradine to beta-blockers in chronic heart failure: Do not rest without lowering the resting heart rate sufficiently
por: Oomman, Abraham, et al.
Publicado: (2018)

Ectopic Atrial Tachycardia in a 12-Month-Old Girl Treated With Ivabradine and Beta-Blocker, a Case Report
por: Michel, Holger, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2s1pkhn2a05gagu6lulv4sffhq