Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress

Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, however, their role in disease processes is poorly understood. Peri...

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Detalles Bibliográficos
Autores principales: Stevenson, Taylor J., Johnson, Rebecca H., Savistchenko, Jimmy, Rustenhoven, Justin, Woolf, Zoe, Smyth, Leon C. D., Murray, Helen C., Faull, Richard L. M., Correia, Jason, Schweder, Patrick, Heppner, Peter, Turner, Clinton, Melki, Ronald, Dieriks, Birger V., Curtis, Maurice A., Dragunow, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569325/
https://www.ncbi.nlm.nih.gov/pubmed/36243723
http://dx.doi.org/10.1038/s41598-022-20261-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569325/
https://www.ncbi.nlm.nih.gov/pubmed/36243723
http://dx.doi.org/10.1038/s41598-022-20261-0

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