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Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry

The neural crest lineage regulatory transcription factors (TFs) form a core regulatory circuitry (CRC) in neuroblastoma (NB) to specify a noradrenergic tumor phenotype. Oncogenic subversion of CRC TFs is well documented, but the role of loss of tumor suppressors plays remains unclear. Zinc-finger TF...

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Detalles Bibliográficos
Autores principales: Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Lei, Haiyan, Shern, Jack F., Thiele, Carol J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569368/
https://www.ncbi.nlm.nih.gov/pubmed/36243768
http://dx.doi.org/10.1038/s41419-022-05314-6