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Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model

The hindered diffusion model postulates that the movement of a signaling molecule through an embryo is affected by tissue geometry and binding-mediated hindrance, but these effects have not been directly demonstrated in vivo. Here, we visualize extracellular movement and binding of individual molecu...

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Detalles Bibliográficos
Autores principales: Kuhn, Timo, Landge, Amit N., Mörsdorf, David, Coßmann, Jonas, Gerstenecker, Johanna, Čapek, Daniel, Müller, Patrick, Gebhardt, J. Christof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569377/
https://www.ncbi.nlm.nih.gov/pubmed/36243734
http://dx.doi.org/10.1038/s41467-022-33704-z