A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo

A clear relationship between the tau assemblies and toxicity has still to be established. To correlate the tau conformation with its proteotoxic effect in vivo, we developed an innovative cell-worm-based approach. HEK293 cells expressing tau P301L under a tetracycline-inducible system (HEK T-Rex) we...

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Detalles Bibliográficos
Autores principales: Natale, Carmina, Barzago, Maria Monica, Colnaghi, Luca, De Luigi, Ada, Orsini, Franca, Fioriti, Luana, Diomede, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569484/
https://www.ncbi.nlm.nih.gov/pubmed/36232578
http://dx.doi.org/10.3390/ijms231911277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569484/
https://www.ncbi.nlm.nih.gov/pubmed/36232578
http://dx.doi.org/10.3390/ijms231911277

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