Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis

Lipid metabolic dysregulation and liver inflammation have been reported to be associated with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain unclear. Hepatitis B virus x protein (HBx) is a risk factor for NASH. Based on metabolomic and transcriptomic screens and public dat...

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Detalles Bibliográficos
Autores principales: Lan, You, Qian, Bo, Huang, Hai-Yan, Wang, Pan, Li, Ting, Yuan, Qi, Zhang, Han-Yu, Lin, Yu-Chun, Lin, Zhong-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569602/
https://www.ncbi.nlm.nih.gov/pubmed/36232960
http://dx.doi.org/10.3390/ijms231911660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569602/
https://www.ncbi.nlm.nih.gov/pubmed/36232960
http://dx.doi.org/10.3390/ijms231911660

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