Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway

The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (Npr1) in mice provokes hypertension and cardiovascular dysfunction. The objective of this study was to determine the mechanisms regulating the development of cardiac fibrosis and dysfunction in Npr1 mutant mice. Npr1 k...

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Detalles Bibliográficos
Autores principales: Subramanian, Umadevi, Ramasamy, Chandramohan, Ramachandran, Samivel, Oakes, Joshua M., Gardner, Jason D., Pandey, Kailash N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569686/
https://www.ncbi.nlm.nih.gov/pubmed/36232788
http://dx.doi.org/10.3390/ijms231911487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569686/
https://www.ncbi.nlm.nih.gov/pubmed/36232788
http://dx.doi.org/10.3390/ijms231911487

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