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Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein

Human ileal bile acid-binding protein (hI-BABP) has a key role in the enterohepatic circulation of bile salts. Its two internal binding sites exhibit positive cooperativity accompanied by a site-selectivity of glycocholate (GCA) and glycochenodeoxycholate (GCDA), the two most abundant bile salts in...

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Detalles Bibliográficos
Autores principales: Horváth, Gergő, Balterer, Bence, Micsonai, András, Kardos, József, Toke, Orsolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569817/
https://www.ncbi.nlm.nih.gov/pubmed/36232642
http://dx.doi.org/10.3390/ijms231911346