Slow Evolution toward “Super-Aggregation” of the Oligomers Formed through the Swapping of RNase A N-Termini: A Wish for Amyloidosis?

Natively monomeric RNase A can oligomerize upon lyophilization from 40% acetic acid solutions or when it is heated at high concentrations in various solvents. In this way, it produces many dimeric or oligomeric conformers through the three-dimensional domain swapping (3D-DS) mechanism involving both...

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Detalles Bibliográficos
Autores principales: Gotte, Giovanni, Butturini, Elena, Bettin, Ilaria, Noro, Irene, Mahmoud Helmy, Alexander, Fagagnini, Andrea, Cisterna, Barbara, Malatesta, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569824/
https://www.ncbi.nlm.nih.gov/pubmed/36232496
http://dx.doi.org/10.3390/ijms231911192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569824/
https://www.ncbi.nlm.nih.gov/pubmed/36232496
http://dx.doi.org/10.3390/ijms231911192

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