Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors

HDAC8 is an important target in several indication areas including childhood neuroblastoma. Several isozyme selective inhibitors of HDAC8 with L-shaped structures have been developed. A theoretical study has suggested that methionine 274 (M274) would act as a “switch” that controls a transient bindi...

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Detalles Bibliográficos
Autores principales: Jänsch, Niklas, Lang, Kim Leoni, Meyer-Almes, Franz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569839/
https://www.ncbi.nlm.nih.gov/pubmed/36233076
http://dx.doi.org/10.3390/ijms231911775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569839/
https://www.ncbi.nlm.nih.gov/pubmed/36233076
http://dx.doi.org/10.3390/ijms231911775

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