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Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome
Lysosomal dysfunction has been proposed as one of the most important pathogenic molecular mechanisms in Parkinson disease (PD). The most significant evidence lies in the GBA gene, which encodes for the lysosomal enzyme β-glucocerebrosidase (β-GCase), considered the main genetic risk factor for spora...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569857/ https://www.ncbi.nlm.nih.gov/pubmed/36233303 http://dx.doi.org/10.3390/ijms231912004 |