Tumor Cell-Specific Retention and Photodynamic Action of Erlotinib-Pyropheophorbide Conjugates

To enhance uptake of photosensitizers by epithelial tumor cells by targeting these to EGFR, pyropheophorbide derivatives were synthesized that had erlotinib attached to different positions on the macrocycle. Although the addition of erlotinib reduced cellular uptake, several compounds showed prolong...

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Detalles Bibliográficos
Autores principales: Tracy, Erin C., Cheruku, Ravindra R., Pandey, Ravindra K., Baumann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569946/
https://www.ncbi.nlm.nih.gov/pubmed/36232384
http://dx.doi.org/10.3390/ijms231911081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569946/
https://www.ncbi.nlm.nih.gov/pubmed/36232384
http://dx.doi.org/10.3390/ijms231911081

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