Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells

Defects in DNA repair pathways have been associated with an improved response to immune checkpoint inhibition (ICI). In particular, patients with the nucleotide excision repair (NER) defect disease Xeroderma pigmentosum (XP) responded impressively well to ICI treatment. Recently, in melanoma patient...

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Detalles Bibliográficos
Autores principales: Banicka, Veronika, Martens, Marie Christine, Panzer, Rüdiger, Schrama, David, Emmert, Steffen, Boeckmann, Lars, Thiem, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569948/
https://www.ncbi.nlm.nih.gov/pubmed/36232946
http://dx.doi.org/10.3390/ijms231911649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569948/
https://www.ncbi.nlm.nih.gov/pubmed/36232946
http://dx.doi.org/10.3390/ijms231911649

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