The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia

This study aimed to extend the body of preclinical research on prototype dual-acting compounds combining the pharmacophores relevant for inhibiting cyclic nucleotide phosphodiesterase 10 (PDE10A) and serotonin 5-HT(1A)/5-HT(7) receptor (5-HT(1A)R/5-HT(7)R) activity into a single chemical entity (com...

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Detalles Bibliográficos
Autores principales: Jastrzębska-Więsek, Magdalena, Kotańska, Magdalena, Grzeszczak, Aleksandra, Jaromin, Anna, Walczak, Maria, Partyka, Anna, Gdula-Argasińska, Joanna, Smolik, Magdalena, Zagórska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569954/
https://www.ncbi.nlm.nih.gov/pubmed/36232749
http://dx.doi.org/10.3390/ijms231911452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569954/
https://www.ncbi.nlm.nih.gov/pubmed/36232749
http://dx.doi.org/10.3390/ijms231911452

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