In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II

The development of in vitro/in vivo translational methods for synergistically acting drug combinations is needed to identify the most effective therapeutic strategies. We performed PBPK/PD modelling for siremadlin, trametinib, and their combination at various dose levels and dosing schedules in an A...

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Detalles Bibliográficos
Autores principales: Witkowski, Jakub, Polak, Sebastian, Rogulski, Zbigniew, Pawelec, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570053/
https://www.ncbi.nlm.nih.gov/pubmed/36233247
http://dx.doi.org/10.3390/ijms231911939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570053/
https://www.ncbi.nlm.nih.gov/pubmed/36233247
http://dx.doi.org/10.3390/ijms231911939

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