Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

Topoisomerases are essential enzymes that recognize and modify the topology of DNA to allow DNA replication and transcription to take place. Topoisomerases are divided into type I topoisomerases, that cleave one DNA strand to modify DNA topology, and type II, that cleave both DNA strands. Topoisomer...

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Detalles Bibliográficos
Autores principales: Bax, Ben D., Sutormin, Dmitry, McDonald, Neil Q., Burley, Glenn A., Shelkovnikova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570105/
https://www.ncbi.nlm.nih.gov/pubmed/36232843
http://dx.doi.org/10.3390/ijms231911541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570105/
https://www.ncbi.nlm.nih.gov/pubmed/36232843
http://dx.doi.org/10.3390/ijms231911541

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