Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening

A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising agent for the treatment of cystic fibrosis. To prevent photoreactions with DNA, hindered substituents were inserted at the 4 and/or 6 position...

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Detalles Bibliográficos
Autores principales: Vaccarin, Christian, Gabbia, Daniela, Franceschinis, Erica, De Martin, Sara, Roverso, Marco, Bogialli, Sara, Sacchetti, Gianni, Tupini, Chiara, Lampronti, Ilaria, Gambari, Roberto, Cabrini, Giulio, Dechecchi, Maria Cristina, Tamanini, Anna, Marzaro, Giovanni, Chilin, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570109/
https://www.ncbi.nlm.nih.gov/pubmed/36232826
http://dx.doi.org/10.3390/ijms231911528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570109/
https://www.ncbi.nlm.nih.gov/pubmed/36232826
http://dx.doi.org/10.3390/ijms231911528

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