Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress

KRIT1 loss-of-function mutations underlie the pathogenesis of Cerebral Cavernous Malformation (CCM), a major vascular disease affecting the central nervous system (CNS). However, KRIT1 is also expressed outside the CNS and modulates key regulators of metabolic and oxy-inflammatory pathways, includin...

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Detalles Bibliográficos
Autores principales: Mastrocola, Raffaella, Aimaretti, Eleonora, Ferreira Alves, Gustavo, Cento, Alessia Sofia, Fornelli, Claudia, Dal Bello, Federica, Ferraris, Chiara, Goitre, Luca, Perrelli, Andrea, Retta, Saverio Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570113/
https://www.ncbi.nlm.nih.gov/pubmed/36232456
http://dx.doi.org/10.3390/ijms231911151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570113/
https://www.ncbi.nlm.nih.gov/pubmed/36232456
http://dx.doi.org/10.3390/ijms231911151

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