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The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10
The bacterial metabolite 4-methylphenol (para-cresol or p-cresol) and its derivative p-cresyl sulfate (pCS) are elevated in the urine and feces of children with autism spectrum disorder (ASD). It has been shown that p-cresol administration induces social behavior deficits and repetitive behavior in...
Autores principales: | Zheng, Yuanpeng, Prince, Naika Z., Peralta Marzal, Lucia N., Ahmed, Sabbir, Garssen, Johan, Perez Pardo, Paula, Kraneveld, Aletta D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570133/ https://www.ncbi.nlm.nih.gov/pubmed/36232346 http://dx.doi.org/10.3390/ijms231911013 |
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