Cargando…

Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis

Thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (6-MP) are used extensively in pediatric and adult patients with inflammatory and neoplastic diseases. They are metabolized to 6-thioguanine nucleotides (6-TGN) or to 6-methyl-mercaptopurine nucleotides (6-MMPN). The balance between 6-TGN and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adam de Beaumais, Tiphaine, Medard, Yves, Amblard, Océane, Goldwirt, Lauriane, Simonin, Mathieu, Martinez Vinson, Christine, Petit, Arnaud, Jacqz-Aigrain, Evelyne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570176/ https://www.ncbi.nlm.nih.gov/pubmed/36233187 http://dx.doi.org/10.3390/ijms231911885

Ejemplares similares

Drug Safety in Translational Paediatric Research: Practical Points to Consider for Paediatric Safety Profiling and Protocol Development: A Scoping Review
por: Aurich, Beate, et al.
Publicado: (2021)

Favorable pharmacokinetic and pharmacodynamic properties of gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukemia FLT3-ITD patients
por: Vignal, Nicolas, et al.
Publicado: (2023)

Contribution of Population Pharmacokinetics of Glycopeptides and Antifungals to Dosage Adaptation in Paediatric Onco-hematological Malignancies: A Review
por: Leroux, Stéphanie, et al.
Publicado: (2021)

Ciprofloxacin safety in paediatrics: a systematic review
por: Adefurin, Abiodun, et al.
Publicado: (2011)

Clinical trials in neonates: How to optimise informed consent and decision making? A European Delphi survey of parent representatives and clinicians
por: Neyro, Virginia, et al.
Publicado: (2018)

Analysis of Paediatric Clinical Trial Characteristics and Activity Over 23 Years—Impact of the European Paediatric Regulation on a Single French Clinical Research Center
por: Arnadottir, Johanna, et al.
Publicado: (2022)

Are Cytochrome P450 CYP2C8 and CYP2C9 Polymorphisms Associated with Ibuprofen Response in Very Preterm Infants?
por: Durrmeyer, Xavier, et al.
Publicado: (2010)

Personalised therapy during preconception and gestation in SLE: usefulness of 6-mercaptopurine metabolite levelswith azathioprine
por: Lambert-Fliszar, Francisca, et al.
Publicado: (2021)

Drug versus placebo randomized controlled trials in neonates: A review of ClinicalTrials.gov registry
por: Desselas, Emilie, et al.
Publicado: (2017)

Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS
por: Supandi, Supandi, et al.
Publicado: (2018)

European survey on the use of prophylactic fluconazole in neonatal intensive care units
por: Kaguelidou, Florentia, et al.
Publicado: (2011)

Safety of fluconazole in paediatrics: a systematic review
por: Egunsola, Oluwaseun, et al.
Publicado: (2013)

Use and safety of azithromycin in neonates: a systematic review
por: Smith, Coral, et al.
Publicado: (2015)

Harmful Effects of the Azathioprine Metabolite 6-Mercaptopurine in Vascular Cells: Induction of Mineralization
por: Prüfer, Jasmin, et al.
Publicado: (2014)

HPLC Quantification of 4-Nitrophenol and its Conjugated Metabolites from Bile
por: Almási, Attila, et al.
Publicado: (2011)

Intracellular metabolites of mercaptopurine in children with lymphoblastic leukaemia: a possible indicator of non-compliance?
por: Lennard, L., et al.
Publicado: (1995)

Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii
por: Nguyen, Nham-Linh, et al.
Publicado: (2020)

Dose-Finding Study of Omeprazole on Gastric pH in Neonates with Gastro-Esophageal Acid Reflux Using a Bayesian Sequential Approach
por: Kaguelidou, Florentia, et al.
Publicado: (2016)

Ureaplasma, bronchopulmonary dysplasia, and azithromycin in European neonatal intensive care units: a survey
por: Pansieri, Claudia, et al.
Publicado: (2014)

Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial
por: Swanson, Garth R., et al.
Publicado: (2022)

ENHANCEMENT OF ANTIBODY SYNTHESIS BY 6-MERCAPTOPURINE
por: Chanmougan, Devendrathan, et al.
Publicado: (1966)

SUPPRESSION OF ALLERGIC UVEITIS BY 6-MERCAPTOPURINE
por: Wirostko, E., et al.
Publicado: (1962)

Design and development of hydrogel nanoparticles for mercaptopurine
por: Senthil, V., et al.
Publicado: (2010)

Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder
por: Konofal, Eric, et al.
Publicado: (2014)

Informed consent for neonatal trials: practical points to consider and a check list
por: Aurich, Beate, et al.
Publicado: (2020)

The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaptopurine-sensitive and -resistant cell culture lines.
por: Johnston, H. P., et al.
Publicado: (1985)

Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections
por: Pandolfini, Chiara, et al.
Publicado: (2012)

Development and validation of a clinical HPLC method for the quantification of hydroxychloroquine and its metabolites in whole blood
por: Qu, Ying, et al.
Publicado: (2015)

STUDIES ON THE ANTI-INFLAMMATORY ACTION OF 6-MERCAPTOPURINE
por: Hurd, Eric R., et al.
Publicado: (1968)

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: THE EFFECT OF 6-MERCAPTOPURINE
por: Hoyer, Leon W., et al.
Publicado: (1962)

Crystal structures of five 6-mercaptopurine derivatives
por: Gomes, Lígia R., et al.
Publicado: (2016)

Serum Creatinine and Serum Cystatin C are Both Relevant Renal Markers to Estimate Vancomycin Clearance in Critically Ill Neonates
por: Leroux, Stéphanie, et al.
Publicado: (2021)

Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis
por: D’Agate, S., et al.
Publicado: (2021)

Validation of a Fast and Simple HPLC-UV Method for the Quantification of Adenosine Phosphates in Human Bronchial Epithelial Cells
por: Juarez-Facio, Ana Teresa, et al.
Publicado: (2021)

THE EFFECT OF 6-MERCAPTOPURINE ON DELAYED HYPERSENSITIVITY IN GUINEA PIGS
por: Hoyer, John R., et al.
Publicado: (1962)

6-mercaptopurine promotes energetic failure in proliferating T cells
por: Fernández-Ramos, Ana A., et al.
Publicado: (2017)

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats
por: Govindappa, Prem Kumar, et al.
Publicado: (2020)

An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial
por: Hill, Louise F., et al.
Publicado: (2020)

Determination and Quantification of the Vinblastine Content in Purple, Red, and White Catharanthus Roseus Leaves Using RP-HPLC Method
por: Abdul Rahim, Rohanizah, et al.
Publicado: (2018)

Implementation of an Enzyme Linked Immunosorbent Assay for the Quantification of Allergenic Egg Residues in Red Wines Using Commercially Available Antibodies
por: Koestel, Carole, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5fvjv5oatl47c5hjnqhmk3fa8n