Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2(P497H) Mutation

Ubiquilin-2 (UBQLN2) mutations lead to familial amyotrophic lateral sclerosis (FALS)/and frontotemporal dementia (FTLD) through unknown mechanisms. The combination of iPSC technology and CRISPR-mediated genome editing technology can generate an iPSC-derived motor neuron (iPSC-MN) model with disease-...

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Detalles Bibliográficos
Autores principales: Zhang, Yiti, Zeng, Baitao, Gu, Ao, Kang, Qinyu, Zhao, Mingri, Peng, Guangnan, Zhou, Miaojin, Liu, Wanxi, Liu, Min, Ding, Lingjie, Liang, Desheng, Liu, Xionghao, Liu, Mujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570184/
https://www.ncbi.nlm.nih.gov/pubmed/36232630
http://dx.doi.org/10.3390/ijms231911333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570184/
https://www.ncbi.nlm.nih.gov/pubmed/36232630
http://dx.doi.org/10.3390/ijms231911333

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