Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation

Recognition of RNA by receptors of the innate immune system is regulated by various posttranslational modifications. Different single 2′-O-ribose (2′-O-) methylations have been shown to convert TLR7/TLR8 ligands into specific TLR8 ligands, so we investigated whether the position of 2′-O-methylation...

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Detalles Bibliográficos
Autores principales: Nicolai, Marina, Steinberg, Julia, Obermann, Hannah-Lena, Solis, Francisco Venegas, Bartok, Eva, Bauer, Stefan, Jung, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570189/
https://www.ncbi.nlm.nih.gov/pubmed/36232437
http://dx.doi.org/10.3390/ijms231911139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570189/
https://www.ncbi.nlm.nih.gov/pubmed/36232437
http://dx.doi.org/10.3390/ijms231911139

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