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Identification of an Optimal TLR8 Ligand by Alternating the Position of 2′-O-Ribose Methylation
Recognition of RNA by receptors of the innate immune system is regulated by various posttranslational modifications. Different single 2′-O-ribose (2′-O-) methylations have been shown to convert TLR7/TLR8 ligands into specific TLR8 ligands, so we investigated whether the position of 2′-O-methylation...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570189/ https://www.ncbi.nlm.nih.gov/pubmed/36232437 http://dx.doi.org/10.3390/ijms231911139 |