Cargando…

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Calpain activation has been implicated in various pathologies, including neurodegeneration. Thus, calpain inhibition could effectively prevent spinal cord injury (SCI) associated with neurodegeneration. In the current study, a dog SCI model was used to evaluate the therapeutic potential of a selecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metwally, Elsayed, Al-Abbadi, Hatim A., Hashem, Mohamed A., Mahmoud, Yasmina K., Ahmed, Eman A., Maaty, Ahmed I., Helal, Ibrahim E., Ahmed, Mahmoud F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570220/ https://www.ncbi.nlm.nih.gov/pubmed/36233068 http://dx.doi.org/10.3390/ijms231911772

Ejemplares similares

Calpain signaling: from biology to therapeutic opportunities in neurodegenerative disorders
por: Metwally, Elsayed, et al.
Publicado: (2023)

Reconstruction of a partial esophageal defect using tunica vaginalis and buccal mucosa autograft: an experimental study in mongrel dogs
por: HASHEM, Mohamed A, et al.
Publicado: (2023)

Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses
por: Helal, Ibrahim E., et al.
Publicado: (2022)

Augmentation cystoplasty in dogs: A comparative study of different tunica vaginalis grafts
por: Ahmed, Mahmoud F., et al.
Publicado: (2022)

Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity
por: Khan, Mushfiquddin, et al.
Publicado: (2018)

Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity
por: Plantier, Vanessa, et al.
Publicado: (2019)

Subclinical endometritis and postpartum ovarian resumption in respect to TNF-α, IL-8 and CRP in Egyptian buffaloes
por: Elsayed, Doaa H., et al.
Publicado: (2020)

Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice
por: El-Attar, Ahmed Mohamed, et al.
Publicado: (2019)

Suppression of neuronal apoptosis and glial activation with modulation of Nrf2/HO-1 and NF-kB signaling by curcumin in streptozotocin-induced diabetic spinal cord central neuropathy
por: Elsayed, Hassan Reda Hassan, et al.
Publicado: (2023)

Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice
por: de la Fuente, Sandra, et al.
Publicado: (2018)

Therapeutic Efficacy of E-64-d, a Selective Calpain Inhibitor, in Experimental Acute Spinal Cord Injury
por: Zhang, Zifeng, et al.
Publicado: (2015)

Clinical and histopathological responses to bee venom phonophoresis in treating venous and diabetic ulcers: a single-blind randomized controlled trial
por: Othman, Eman M., et al.
Publicado: (2023)

Effect of Spinal Shortening for Protection of Spinal Cord Function in Canines with Spinal Cord Angulation
por: Lu, Qiu-An, et al.
Publicado: (2019)

Ormosanine improves neuronal functions in spinal cord-injured rats by blocking peroxynitrite/calpain activity
por: An, Yan, et al.
Publicado: (2020)

Case Report: Acute Spinal Cord Myelopathy in Patients With COVID-19
por: Khedr, Eman M., et al.
Publicado: (2020)

Formulation and Optimization of Nanospanlastics for Improving the Bioavailability of Green Tea Epigallocatechin Gallate
por: Mazyed, Eman A., et al.
Publicado: (2021)

Alleviating Effects of Vitamins C and E Supplementation on Oxidative Stress, Hematobiochemical, and Histopathological Alterations Caused by Copper Toxicity in Broiler Chickens
por: Hashem, Mohamed A., et al.
Publicado: (2021)

Calpains in cyanobacteria and the origin of calpains
por: Vešelényiová, Dominika, et al.
Publicado: (2022)

Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma
por: Arbaga, Ali, et al.
Publicado: (2021)

Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy
por: Abdallah, Mohamed A., et al.
Publicado: (2020)

Heart Rate Variability as A Predictor of Hypotension Following Spinal Anesthesia for Elective Caesarian Section in Preeclamptic Parturients: A Descriptive Observational Study
por: Shehata, Jehan Helmy, et al.
Publicado: (2019)

Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil
por: Ahmed, Mohamed S., et al.
Publicado: (2020)

Prevalence of Virulence Genes and Their Association with Antimicrobial Resistance Among Pathogenic E. coli Isolated from Egyptian Patients with Different Clinical Infections
por: Abd El-Baky, Rehab Mahmoud, et al.
Publicado: (2020)

Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits
por: Teaima, Mahmoud Hasan, et al.
Publicado: (2020)

Histopathological lesions in reproductive organs, distal spinal cord and peripheral nerves of horses naturally infected with Trypanosoma equiperdum
por: Yasine, Ahmed, et al.
Publicado: (2019)

Evaluation of calpain T-cell epitopes as vaccine candidates against experimental Leishmania major infection: a pilot study
por: Brakat, Reham, et al.
Publicado: (2022)

Comparative evaluation of gold nanoparticles and Alum as immune enhancers against rabies vaccine and related immune reactivity, physiological, and histopathological alterations: in vivo study
por: El-Hennamy, Rehab Essam El-Din, et al.
Publicado: (2023)

Biomarkers in Spinal Cord Injury: Prognostic Insights and Future Potentials
por: Albayar, Ahmed A., et al.
Publicado: (2019)

Dietary Parsley Seed Mitigates Methomyl-Induced Impaired Growth Performance, Hemato-Immune Suppression, Oxidative Stress, Hepato-Renal Damage, and Pseudomonas aeruginosa Susceptibility in Oreochromis niloticus
por: El-Houseiny, Walaa, et al.
Publicado: (2022)

Association between oxidative stress and cord serum lipids in relation to delayed cord clamping in term neonates
por: Moustafa, Asmaa N., et al.
Publicado: (2017)

Rationally designed nanocarriers for intranasaltherapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
por: Sallam, Marwa Ahmed, et al.
Publicado: (2016)

Etanercept Prevents Histopathological Damage after Spinal Cord Injury in Rats
por: Hasturk, Askin Esen, et al.
Publicado: (2018)

Pilot Study on Feasibility of Sensory-Enhanced Rehabilitation in Canine Spinal Cord Injury
por: Lewis, Melissa J., et al.
Publicado: (2022)

Antitoxic Effects of Curcumin against Obesity-Induced Multi-Organs' Biochemical and Histopathological Abnormalities in an Animal Model
por: Hassan, Mohammed H., et al.
Publicado: (2022)

Calpain-2 participates in the process of calpain-1 inactivation
por: Shinkai-Ouchi, Fumiko, et al.
Publicado: (2020)

Glomerulonephritis Histopathological Pattern Change
por: AlYousef, Anas, et al.
Publicado: (2020)

Histopathological, Immunohistochemical and Biochemical Studies of Murine Hepatosplenic Tissues Affected by Chronic Toxoplasmosis
por: Yahia, Samah Hassan, et al.
Publicado: (2022)

Enhance the performance of photovoltaic solar panels by a self-cleaning and hydrophobic nanocoating
por: Tayel, Samir Ahmed, et al.
Publicado: (2022)

Decorin treatment of spinal cord injury
por: Esmaeili, Maryam, et al.
Publicado: (2014)

The hematological impact of umbilical cord milking versus delayed cord clamping in premature neonates: a randomized controlled trial
por: Atia, Hytham, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h6cochbllis2kumb24g6al0npi