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Effective Modulation by Lacosamide on Cumulative Inhibition of I(Na) during High-Frequency Stimulation and Recovery of I(Na) Block during Conditioning Pulse Train
The effects of lacosamide (LCS, Vimpat(®)), an anti-convulsant and analgesic, on voltage-gated Na(+) current (I(Na)) were investigated. LCS suppressed both the peak (transient, I(Na(T))) and sustained (late, I(Na(L))) components of I(Na) with the IC(50) values of 78 and 34 μM found in GH(3) cells an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570249/ https://www.ncbi.nlm.nih.gov/pubmed/36233266 http://dx.doi.org/10.3390/ijms231911966 |