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Effective Modulation by Lacosamide on Cumulative Inhibition of I(Na) during High-Frequency Stimulation and Recovery of I(Na) Block during Conditioning Pulse Train

The effects of lacosamide (LCS, Vimpat(®)), an anti-convulsant and analgesic, on voltage-gated Na(+) current (I(Na)) were investigated. LCS suppressed both the peak (transient, I(Na(T))) and sustained (late, I(Na(L))) components of I(Na) with the IC(50) values of 78 and 34 μM found in GH(3) cells an...

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Detalles Bibliográficos
Autores principales:	Wu, Po-Ming, Lin, Yu-Ching, Chiang, Chi-Wu, Cho, Hsin-Yen, Chuang, Tzu-Hsien, Yu, Meng-Cheng, Wu, Sheng-Nan, Tu, Yi-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570249/ https://www.ncbi.nlm.nih.gov/pubmed/36233266 http://dx.doi.org/10.3390/ijms231911966

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