Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but its overdose can cause acute liver failure. The dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1, NR0B1), is an orphan nuclear receptor that acts as a transcriptiona...

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Detalles Bibliográficos
Autores principales: Suh, Young-Joo, Yun, Hyo-Jeong, Kim, Yu-Bin, Kang, Eun-Jung, Choi, Jung Hyeon, Choi, Young-Keun, Lee, In-Bok, Choi, Dong-Hee, Seo, Yun Jeong, Noh, Jung-Ran, Lee, Jong-Soo, Kim, Yong-Hoon, Lee, Chul-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570285/
https://www.ncbi.nlm.nih.gov/pubmed/36233086
http://dx.doi.org/10.3390/ijms231911786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570285/
https://www.ncbi.nlm.nih.gov/pubmed/36233086
http://dx.doi.org/10.3390/ijms231911786

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