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MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the nucleus where it regulates a wide range of genes in response to metabolic dysfunction. It is colocalized to mitochondria in vari...

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Autores principales: Mohtashami, Zahra, Singh, Mithalesh K., Salimiaghdam, Nasim, Ozgul, Mustafa, Kenney, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570330/
https://www.ncbi.nlm.nih.gov/pubmed/36233287
http://dx.doi.org/10.3390/ijms231911991
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author Mohtashami, Zahra
Singh, Mithalesh K.
Salimiaghdam, Nasim
Ozgul, Mustafa
Kenney, M. Cristina
author_facet Mohtashami, Zahra
Singh, Mithalesh K.
Salimiaghdam, Nasim
Ozgul, Mustafa
Kenney, M. Cristina
author_sort Mohtashami, Zahra
collection PubMed
description MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the nucleus where it regulates a wide range of genes in response to metabolic dysfunction. It is colocalized to mitochondria in various tissues and is found in plasma, but the levels decline with age. Since MOTS-c has important cellular functions as well as a possible hormonal role, it has been shown to have beneficial effects on age-related diseases including Diabetes, Cardiovascular diseases, Osteoporosis, postmenopausal obesity and Alzheimer. Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capability, which potentially can be reversed with MOTS-c treatment. This review examines the latest findings on biological effects of MOTS-c as a nuclear regulatory peptide and focuses on the role of MOTS-c in aging and age-related disorders, including mechanisms of action and therapeutic potential.
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spelling pubmed-95703302022-10-17 MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases Mohtashami, Zahra Singh, Mithalesh K. Salimiaghdam, Nasim Ozgul, Mustafa Kenney, M. Cristina Int J Mol Sci Review MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the nucleus where it regulates a wide range of genes in response to metabolic dysfunction. It is colocalized to mitochondria in various tissues and is found in plasma, but the levels decline with age. Since MOTS-c has important cellular functions as well as a possible hormonal role, it has been shown to have beneficial effects on age-related diseases including Diabetes, Cardiovascular diseases, Osteoporosis, postmenopausal obesity and Alzheimer. Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capability, which potentially can be reversed with MOTS-c treatment. This review examines the latest findings on biological effects of MOTS-c as a nuclear regulatory peptide and focuses on the role of MOTS-c in aging and age-related disorders, including mechanisms of action and therapeutic potential. MDPI 2022-10-09 /pmc/articles/PMC9570330/ /pubmed/36233287 http://dx.doi.org/10.3390/ijms231911991 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohtashami, Zahra
Singh, Mithalesh K.
Salimiaghdam, Nasim
Ozgul, Mustafa
Kenney, M. Cristina
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title_full MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title_fullStr MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title_full_unstemmed MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title_short MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
title_sort mots-c, the most recent mitochondrial derived peptide in human aging and age-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570330/
https://www.ncbi.nlm.nih.gov/pubmed/36233287
http://dx.doi.org/10.3390/ijms231911991
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