Imatinib Mesylate Induces Necroptotic Cell Death and Impairs Autophagic Flux in Human Cardiac Progenitor Cells

The receptor tyrosine kinase inhibitor imatinib improves patient cancer survival but is linked to cardiotoxicity. This study investigated imatinib’s effects on cell viability, apoptosis, autophagy, and necroptosis in human cardiac progenitor cells in vitro. Imatinib reduced cell viability (75.9 ± 2....

Descripción completa

Detalles Bibliográficos
Autores principales: Walmsley, Robert, Steele, Derek S., Ellison-Hughes, Georgina M., Papaspyros, Sotiris, Smith, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570431/
https://www.ncbi.nlm.nih.gov/pubmed/36233113
http://dx.doi.org/10.3390/ijms231911812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570431/
https://www.ncbi.nlm.nih.gov/pubmed/36233113
http://dx.doi.org/10.3390/ijms231911812

Ejemplares similares