Formulation, Characterisation and Evaluation of the Antihypertensive Peptides, Isoleucine-Proline-Proline and Leucine-Lysine-Proline in Chitosan Nanoparticles Coated with Zein for Oral Drug Delivery

Isoleucine-Proline-Proline (IPP) and Leucine-Lysine-Proline (LKP) are food-derived tripeptides whose antihypertensive functions have been demonstrated in hypertensive rat models. However, peptides display low oral bioavailability due to poor intestinal epithelial permeability and instability. IPP an...

Descripción completa

Detalles Bibliográficos
Autores principales: Khalid Danish, Minna, Gleeson, John P., Brayden, David J., Byrne, Hugh J., Frías, Jesus M., Ryan, Sinéad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570432/
https://www.ncbi.nlm.nih.gov/pubmed/36232463
http://dx.doi.org/10.3390/ijms231911160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570432/
https://www.ncbi.nlm.nih.gov/pubmed/36232463
http://dx.doi.org/10.3390/ijms231911160

Ejemplares similares