The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating

Lens gap junctions (GJs) formed by Cx46 and Cx50 are important to keep lens transparency. Functional studies on Cx46 and Cx50 GJs showed that the V(j)-gating, single channel conductance (γ(j)), gating polarity, and/or channel open stability could be modified by the charged residues in the amino term...

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Detalles Bibliográficos
Autores principales: Jaradat, Roa’a, Li, Xiaole, Chen, Honghong, Stathopulos, Peter B., Bai, Donglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570504/
https://www.ncbi.nlm.nih.gov/pubmed/36232905
http://dx.doi.org/10.3390/ijms231911605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570504/
https://www.ncbi.nlm.nih.gov/pubmed/36232905
http://dx.doi.org/10.3390/ijms231911605

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