Cargando…

Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs

In designing effective siRNAs for a specific mRNA target, it is critically important to have predictive models for the potency of siRNAs. None of the published methods characterized the chemical structures of individual nucleotides constituting a siRNA molecule; therefore, they cannot predict the po...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Xialan, Zheng, Weifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570765/
https://www.ncbi.nlm.nih.gov/pubmed/36234948
http://dx.doi.org/10.3390/molecules27196412