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Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs
In designing effective siRNAs for a specific mRNA target, it is critically important to have predictive models for the potency of siRNAs. None of the published methods characterized the chemical structures of individual nucleotides constituting a siRNA molecule; therefore, they cannot predict the po...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570765/ https://www.ncbi.nlm.nih.gov/pubmed/36234948 http://dx.doi.org/10.3390/molecules27196412 |