A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists

Four sets of diastereomeric C9-alkenyl 5-phenylmorphans, varying in the length of the C9-alkenyl chain, were designed to examine the effect of these spatially distinct ligands on opioid receptors. Functional activity was obtained by forskolin-induced cAMP accumulation assays and several compounds we...

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Detalles Bibliográficos
Autores principales: Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Goldberg, Alexander, Xie, Bing, Shi, Lei, Paronis, Carol A., Bergman, Jack, Nassehi, Nima, Selley, Dana E., Imler, Gregory H., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570967/
https://www.ncbi.nlm.nih.gov/pubmed/36234992
http://dx.doi.org/10.3390/molecules27196455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570967/
https://www.ncbi.nlm.nih.gov/pubmed/36234992
http://dx.doi.org/10.3390/molecules27196455

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