Design and Synthesis of Coumarin Derivatives as Cytotoxic Agents through PI3K/AKT Signaling Pathway Inhibition in HL60 and HepG2 Cancer Cells

In this study, a series of coumarin derivatives, either alone or as hybrids with cinnamic acid, were synthesized and evaluated for their cytotoxicity against a panel of cancer cells using the MTT assay. Then, the most active compounds were inspected for their mechanism of cytotoxicity by cell-cycle...

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Detalles Bibliográficos
Autores principales: Kishk, Safaa M., Eltamany, Enas E., Nafie, Mohamed S., Khinkar, Roaa M., Hareeri, Rawan H., Elhady, Sameh S., Yassen, Asmaa S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571264/
https://www.ncbi.nlm.nih.gov/pubmed/36235247
http://dx.doi.org/10.3390/molecules27196709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571264/
https://www.ncbi.nlm.nih.gov/pubmed/36235247
http://dx.doi.org/10.3390/molecules27196709

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