Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei

New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small library of analogs of the antitrypanosomal hit (MMV675968) available at MMV as solid materials was screened for antitrypanosomal activity. In s...

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Detalles Bibliográficos
Autores principales: Dize, Darline, Tata, Rolland Bantar, Keumoe, Rodrigue, Kouipou Toghueo, Rufin Marie, Tchatat, Mariscal Brice, Njanpa, Cyrille Ngansop, Tchuenguia, Vianey Claire, Yamthe, Lauve Tchokouaha, Fokou, Patrick Valere Tsouh, Laleu, Benoît, Duffy, James, Bishop, Ozlem Tastan, Boyom, Fabrice Fekam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571290/
https://www.ncbi.nlm.nih.gov/pubmed/36235118
http://dx.doi.org/10.3390/molecules27196574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571290/
https://www.ncbi.nlm.nih.gov/pubmed/36235118
http://dx.doi.org/10.3390/molecules27196574

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