Cargando…

ENPP1 deletion causes mouse osteoporosis via the MKK3/p38 MAPK/PCNA signaling pathway

BACKGROUND: Apart from the current understanding of enzyme function, the mechanism of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) deficiency-associated osteoporosis is unknown. We aimed to explore the changes in the expression of signaling pathways of bone tissues involved in Enpp1 de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qiang, Gao, Zhiqiang, Guo, Kai, Lu, Jiawei, Wang, Feng, Huang, Yufeng, Wu, Desheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571425/ https://www.ncbi.nlm.nih.gov/pubmed/36243801 http://dx.doi.org/10.1186/s13018-022-03349-1

Ejemplares similares

Enpp1 deficiency caused chondrocyte apoptosis by inhibiting AMPK signaling pathway
por: Gao, Zhiqiang, et al.
Publicado: (2023)

Balance between MKK6 and MKK3 Mediates p38 MAPK Associated Resistance to Cisplatin in NSCLC
por: Galan-Moya, Eva M., et al.
Publicado: (2011)

Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells
por: Castro-Torres, Rubén Darío, et al.
Publicado: (2021)

Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer
por: Stramucci, Lorenzo, et al.
Publicado: (2018)

Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency
por: Oheim, Ralf, et al.
Publicado: (2019)

Gamma synuclein promotes cancer metastasis through the MKK3/6-p38MAPK cascade
por: Liu, Jieya, et al.
Publicado: (2022)

Human Umbilical Cord Wharton Jelly Cells Treatment Prevents Osteoporosis Induced by D-Galactose
por: Wang, Qiang, et al.
Publicado: (2022)

Approaching the challenges of MKK3/p38delta MAPK targeting for therapeutic purpose in colorectal cancer
por: Stramucci, Lorenzo, et al.
Publicado: (2019)

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss
por: Boyle, David L., et al.
Publicado: (2014)

Correction: Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss
por: Boyle, David L., et al.
Publicado: (2014)

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer
por: Stramucci, Lorenzo, et al.
Publicado: (2019)

RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway
por: Guo, Rui, et al.
Publicado: (2022)

MKK3 Was Involved in Larval Settlement of the Barnacle Amphibalanus amphitrite through Activating the Kinase Activity of p38MAPK
por: Zhang, Gen, et al.
Publicado: (2013)

Crystal structure of the phosphorylated Arabidopsis MKK5 reveals activation mechanism of MAPK kinases : Activation mechanism of AtMKK5
por: Pei, Chao-Jun, et al.
Publicado: (2022)

Integration analysis of MKK and MAPK family members highlights potential MAPK signaling modules in cotton
por: Zhang, Xueying, et al.
Publicado: (2016)

Tubeimoside-2 Triggers Methuosis in Hepatocarcinoma Cells through the MKK4–p38α Axis
por: Gan, Yichao, et al.
Publicado: (2023)

Molecular mechanism by which Apis cerana cerana MKK6 (AccMKK6)-mediated MAPK cascades regulate the oxidative stress response
por: Wang, Xinxin, et al.
Publicado: (2018)

Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma
por: Chiang, Chengyao, et al.
Publicado: (2020)

SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma
por: Wang, Yulan, et al.
Publicado: (2016)

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation
por: Romero-Becerra, Rafael, et al.
Publicado: (2022)

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1
por: Onyedibe, Kenneth I., et al.
Publicado: (2019)

Assessing developmental roles of MKK4 and MKK7 in vitro
por: Wang, Jingcai, et al.
Publicado: (2012)

TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase
por: Pattison, Michael J., et al.
Publicado: (2016)

PSAT219 Renal Phosphate Wasting Caused by ENPP-1 mutation.
por: Madahar, Inderpreet, et al.
Publicado: (2022)

A New Enpp1 allele, Enpp1(ttw-Ham), Identified in an ICR Closed Colony
por: Takabayashi, Shuji, et al.
Publicado: (2014)

The MKK2a Gene Involved in the MAPK Signaling Cascades Enhances Populus Salt Tolerance
por: Wang, Jiali, et al.
Publicado: (2022)

Role of ENPP1 on Adipocyte Maturation
por: Liang, Jian, et al.
Publicado: (2007)

ENPP2 Methylation in Health and Cancer
por: Panagopoulou, Maria, et al.
Publicado: (2021)

Effects of etidronate on the Enpp1(−/−) mouse model of generalized arterial calcification of infancy
por: HUESA, CARMEN, et al.
Publicado: (2015)

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases
por: Toyoshima, Fumiko, et al.
Publicado: (1997)

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
por: Rasheed, Zafar, et al.
Publicado: (2010)

ENPP1 Immunobiology as a Therapeutic Target
por: Ruiz-Fernández de Córdoba, Borja, et al.
Publicado: (2023)

Ablation of Enpp6 Results in Transient Bone Hypomineralization
por: Dillon, Scott, et al.
Publicado: (2020)

The MKKK62-MKK3-MAPK7/14 module negatively regulates seed dormancy in rice
por: Mao, Xingxue, et al.
Publicado: (2019)

Spontaneous asj-2J Mutant Mouse as a Model for Generalized Arterial Calcification of Infancy: A Large Deletion/Insertion Mutation in the Enpp1 Gene
por: Li, Qiaoli, et al.
Publicado: (2014)

Deletion of the Pyrophosphate Generating Enzyme ENPP1 Rescues Craniofacial Abnormalities in the TNAP(−/−) Mouse Model of Hypophosphatasia and Reveals FGF23 as a Marker of Phenotype Severity
por: Nam, Hwa Kyung, et al.
Publicado: (2022)

Comparative analysis of MAPK and MKK gene families reveals differential evolutionary patterns in Brachypodium distachyon inbred lines
por: Jiang, Min, et al.
Publicado: (2021)

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice
por: Morganti, Josh M., et al.
Publicado: (2019)

MKK3 as oncotarget
por: Bossi, Gianluca
Publicado: (2016)

Genome-Wide Identification and Analysis of MKK and MAPK Gene Families in Brassica Species and Response to Stress in Brassica napus
por: Wang, Zhen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8sk24l25fbcmlrc0770am5mdh7