Optimization and Identification of Single Mutation in Hemoglobin Variants with 2,2,2 Trifluoroethanol Modified Digestion Method and Nano−LC Coupled MALDI MS/MS

Background: Hemoglobin (Hb) variants arise due to point mutations in globin chains and their pathological treatments rely heavily on the identification of the nature and location of the mutation in the globin chains. Traditional methods for diagnosis such as HPLC and electrophoresis have their own l...

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Detalles Bibliográficos
Autores principales: Dasauni, Pushpanjali, Singh, Nirpendra, Chhabra, Varun, Mahapatra, Manoranjan, Saxena, Renu, Kundu, Suman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572498/
https://www.ncbi.nlm.nih.gov/pubmed/36234894
http://dx.doi.org/10.3390/molecules27196357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572498/
https://www.ncbi.nlm.nih.gov/pubmed/36234894
http://dx.doi.org/10.3390/molecules27196357

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