Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy

Protein arginine methyltransferases 5 (PRMT5) is a clinically promising epigenetic target that is upregulated in a variety of tumors. Currently, there are several PRMT5 inhibitors under preclinical or clinical development, however the established clinical inhibitors show favorable toxicity. Thus, it...

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Detalles Bibliográficos
Autores principales: Tang, Yixuan, Huang, Shihui, Chen, Xingxing, Huang, Junzhang, Lin, Qianwen, Huang, Lei, Wang, Shuping, Zhu, Qihua, Xu, Yungen, Zou, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572541/
https://www.ncbi.nlm.nih.gov/pubmed/36235174
http://dx.doi.org/10.3390/molecules27196637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572541/
https://www.ncbi.nlm.nih.gov/pubmed/36235174
http://dx.doi.org/10.3390/molecules27196637

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