Polysorbates versus Hydroxypropyl Beta-Cyclodextrin (HPβCD): Comparative Study on Excipient Stability and Stabilization Benefits on Monoclonal Antibodies

Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption. To date, around 70% of marketed therapeutic antibodies contain either PS 20 or PS 80 in their formulations. However, polys...

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Detalles Bibliográficos
Autores principales: Zhang, Hailong, Hong, Shiqi, Tan, Sarah Si Kai, Peng, Tao, Goh, Lucas Yuan Hao, Lam, Kwan Hang, Chow, Keat Theng, Gokhale, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572940/
https://www.ncbi.nlm.nih.gov/pubmed/36235038
http://dx.doi.org/10.3390/molecules27196497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572940/
https://www.ncbi.nlm.nih.gov/pubmed/36235038
http://dx.doi.org/10.3390/molecules27196497

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